?ú?·基本信息

?ú?·名称: PLGA
通用名:  
化学系列:  
浏览人次: 2503
发 布 者: sdsyxs
发布日期: 2011-04-13 15:37:23
?ú?·介绍
?ú????????????——
???¨?é?á-???ù???á?????????¨PLGA??
 
 
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???¨?é?á-???ù???á?????????¨PLGA???????????ú???????????????????????????????ú???à?????????????ú???é?á?????ù???á?????????????????ú????×???????????????????±???????????
PLA??PLLA?òPLGA——???úFDA???ú×??????¨?????¨?????ú??????????????
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???????????????????????????ò×?????????×??????????????????????????¤?????é??????·??????????÷??????×é·???
??×?????????——Zoladex® ?¨Zenica??????????????
    ???????±??×??????¤???ò???????????±??1???????ù??PLGA??????????????????
?à?????ò×?????——LHRH?à???????ò?¨?????°????°???
?ú???????¨triptorelin??——·¨?úIpsen??????·???1986?ê????????????1??????
??±??????¨leuprorelin??——????1?????????ò×?????????±????????§??????????·??? 1989?ê???????ú??????
±?°±?????¨alarelin LHRH-A??——×?????????????????????????
???????ò×?????——??????×????????¨single dose vaccine??
????·??à?????¨tetannstoxoid,TT?????ò×???????????×????ó??????????????????·????????????????????ú?ú??????????????????
 
?????ú?·????

 

?ú?·????
??  ??
????????
dl/g??
·?×???
?¨?ò??
??×ó??±?????  Poly-L-lactide

PLLA

0.5??6
1??40
???é?á   Poly-DL-lactide
PLA
0.15??5
0.5??40
???¨?é?á-???ù???á????????90/10
Poly(DL-lactide-co-glycolide) 90/10
PLGA 90/10
0.15??2.5
0.5??20
???¨?é?á-???ù???á????????80/20
Poly(DL-lactide-co-glycolide) 80/20
PLGA 80/20
0.15??1.5
0.5??15
???¨?é?á-???ù???á????????75/25
Poly(DL-lactide-co-glycolide) 75/25
PLGA 75/25
0.15??1.5
0.5??15
???¨?é?á-???ù???á????????70/30
Poly(DL-lactide-co-glycolide) 70/30
PLGA 70/30
0.15??1.2
0.5??12
???¨?é?á-???ù???á????????60/40
Poly(DL-lactide-co-glycolide) 60/40
PLGA 60/40
0.15??0.9
0.5??10
???¨?é?á-???ù???á????????50/50
Poly(DL-lactide-co-glycolide) 50/50
PLGA 50/50
0.15??0.8
0.5??10
*???????????¨?????????????????×?é??????25±0.05 ????
*PLGA??????????PLGA 75/25??PLGA 50/50???????ü±????ú?·?è??????

 

 
?????ú?·????
???é?á?¨PLA??PLLA???????¨?é?á-???ù???á?????????¨PLGA???ú?·????°ü?¨??
???????¨???????ì?é?????ú???????????????ì?é
“?????¨??”?????ì?é??
?????????ú?????·2000?ê°????ú?????à?ú?·???????ó????±??·?????????ì?é??
????×??? ±??·???????×?é????·??ò±??????×???????????ò??????????
????±???
?¨1??±??·???ì?????ü?????×???????·?????×??????
  ?¨2??±??·??1H???????????×???????·?????×??????
???ì?é?? ?????????ú????2000?ê°??????????·?????à?????ó????±??·???????á?????????§??????×????ü???????????é???????????°???ú???????????ì?é????±í1??
 
±í1??PLGA?÷???ì?é?????¨?á??
?ú??
2003111205
2003111801
2003111802
?á??
4.90
4.31
4.83
????%
0.005
0.006
0.006
???á????%
0.014
0.013
0.017
?????×?é%
0.042
0.043
0.058
?????§??%
0.5449
0.5010
0.4785
??×????ü%
0.1533
0.1449
0.1318
??????
< °??ò·?????
< °??ò·?????
< °??ò·?????
?é??%
0.00002
0.00002
0.00002
????%
0.0080
0.0025
0.0082
 
?¤??  ?????¤??·¨???¨??[η]??0.14??2.5 dl/g?¨??·???25±0.05??????
?????×?é?????á??????????  ?????ú?????????????¨·¨?¨???ú????2000?ê°???????????P????·¨?????¨?????????×?é??????????0.06%?????????????á?????????ù??????0.5%??
????????×é?????¨?? ????PLGA??????1H?????????×?¨1H NMR????????·?±????ó????????×é??????±??¨LA/GA??90/10??50/50????
??·?×??????¨??  ?????????????×?ù????·????÷???à???ù????30?????????????????ì???÷??±ê?ù??????·?×?????????±???????????GPCר???í??????±ê×??ú?????????í??????????·?×????°·?×???·????¨Mw??5000??200000??Mw/Mn??1.2??2.0????
??????????????  ???????ò·?×????????????????????????????ù????????????